Therapeutic drug monitoring of antithyroid drugs in pregnancy: the knowledge gaps.
نویسندگان
چکیده
Despite being a common condition in pregnancy, and despite propylthiouracil (PTU) being perceived as safer than methimazole, there are virtually no epidemiological controlled studies on malformation rate an neurobehavioral outcomes with the former. This knowledge gap must be filled to ensure fetal safety.
منابع مشابه
A Review on Therapeutic Drug Monitoring of Immunosuppressant Drugs
Immunosuppressants require therapeutic drug monitoring because of their narrow therapeutic index and significant inter-individual variability in blood concentrations. This variability can be because of factors like drug-nutrient interactions, drug-disease interactions, renal-insufficiency, inflammation and infection, gender, age, polymorphism and liver mass. Drug monitoring is widely practiced ...
متن کاملAntithyroid Drugs
The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...
متن کاملAntithyroid Drugs
The thionamide drugs, i.e. carbimazole and its metabolite methimazole (MMI), andpropylthiouracil (PTU) have extensively been used in the management of various forms ofhyperthyroidism over the past eight decades. This review aims to summarize different aspectsof these outstanding medications. Thionamides have shown their own acceptable efficacy andeven safety profiles in ...
متن کاملEffects of methimazole and propylthiouracil exposure during pregnancy on the risk of neonatal congenital malformations: A meta-analysis
OBJECTIVE The aim of this study was to determine the effect of exposure to different antithyroid drugs during pregnancy on the incidence of neonatal congenital malformations. METHODS A meta-analysis was performed to compare the incidence of neonatal congenital malformations after exposure to different antithyroid drugs during pregnancy. Twelve studies that met the inclusion criteria were incl...
متن کاملA survey on midwives knowledge about drug usage in pregnancy and lactstion in the city of Kerman
Drugs are often used by women during pregnancy & lactstion. Midwives are among those giving service in maternal and child health programs, and are in contact with groups of pregnant & lactation women. In order to determine the midwives knowledge about drug usage in pregnancy and lactstion, this survey was carried out on all midwives of Kerman city ( n =69) in June 1995, using a questionnaire ba...
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ورودعنوان ژورنال:
- Therapeutic drug monitoring
دوره 28 4 شماره
صفحات -
تاریخ انتشار 2006